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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD4
All Species:
16.06
Human Site:
S427
Identified Species:
35.33
UniProt:
Q9NXE4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXE4
NP_060221.2
827
93352
S427
D
S
Q
P
R
C
V
S
E
K
W
A
P
F
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543560
827
93189
S427
D
C
Q
A
R
C
V
S
E
R
W
A
P
F
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZPR5
823
93257
S426
D
P
Q
P
R
C
V
S
E
K
W
A
P
F
I
Rat
Rattus norvegicus
NP_001161278
823
93261
S426
D
S
Q
P
R
C
V
S
E
R
W
A
P
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509989
509
58534
M148
V
S
P
K
N
A
L
M
V
F
R
V
A
K
V
Chicken
Gallus gallus
XP_415236
827
94779
S428
E
L
L
P
R
S
V
S
E
K
W
A
A
F
I
Frog
Xenopus laevis
Q5XHG1
824
93777
V426
G
E
M
Q
N
R
N
V
P
E
K
W
S
T
F
Zebra Danio
Brachydanio rerio
Q6PFJ7
791
89972
D422
L
N
R
A
M
R
T
D
L
V
N
A
K
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650124
767
86929
F403
I
S
S
C
F
D
G
F
I
I
D
N
L
I
M
Honey Bee
Apis mellifera
XP_623882
744
86631
P383
A
I
F
Q
Q
L
L
P
R
F
M
R
T
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784153
874
98584
P427
Y
H
K
D
I
H
S
P
L
R
S
H
L
G
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
92
N.A.
89.8
90.3
N.A.
46.1
74.9
66.2
60.5
N.A.
24.2
29.5
N.A.
31
Protein Similarity:
100
N.A.
N.A.
94.5
N.A.
93.8
93.9
N.A.
51.8
83.9
77.6
71.9
N.A.
42.2
47.4
N.A.
49.2
P-Site Identity:
100
N.A.
N.A.
80
N.A.
86.6
86.6
N.A.
13.3
60
0
6.6
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
93.3
100
N.A.
20
73.3
6.6
20
N.A.
13.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
19
0
10
0
0
0
0
0
55
19
0
19
% A
% Cys:
0
10
0
10
0
37
0
0
0
0
0
0
0
0
0
% C
% Asp:
37
0
0
10
0
10
0
10
0
0
10
0
0
10
0
% D
% Glu:
10
10
0
0
0
0
0
0
46
10
0
0
0
0
0
% E
% Phe:
0
0
10
0
10
0
0
10
0
19
0
0
0
46
10
% F
% Gly:
10
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% G
% His:
0
10
0
0
0
10
0
0
0
0
0
10
0
0
0
% H
% Ile:
10
10
0
0
10
0
0
0
10
10
0
0
0
10
28
% I
% Lys:
0
0
10
10
0
0
0
0
0
28
10
0
10
10
0
% K
% Leu:
10
10
10
0
0
10
19
0
19
0
0
0
19
0
10
% L
% Met:
0
0
10
0
10
0
0
10
0
0
10
0
0
0
10
% M
% Asn:
0
10
0
0
19
0
10
0
0
0
10
10
0
10
0
% N
% Pro:
0
10
10
37
0
0
0
19
10
0
0
0
37
0
0
% P
% Gln:
0
0
37
19
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
46
19
0
0
10
28
10
10
0
0
0
% R
% Ser:
0
37
10
0
0
10
10
46
0
0
10
0
10
0
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
10
10
0
% T
% Val:
10
0
0
0
0
0
46
10
10
10
0
10
0
0
28
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
46
10
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _